Two sample MR report
CST3_Monocyte (Mono) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | -0.1045871 | 0.3917289 | 0.8067793 |
| Weighted median | 5 | -0.0364857 | 0.0177010 | 0.0392824 |
| Inverse variance weighted | 5 | -0.0371697 | 0.0146814 | 0.0113494 |
| Simple mode | 5 | -0.0381224 | 0.0224837 | 0.1652130 |
| Weighted mode | 5 | -0.0388507 | 0.0230563 | 0.1672640 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0448690 | 3 | 0.9975060 |
| Inverse variance weighted | 0.0745298 | 4 | 0.9993227 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0296813 | 0.1723424 | 0.874225 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 7.92e-05 | 0 | TRUE | 0.3978323 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
